聚乙醇酸/聚乙二醇/聚乙醇酸三嵌段聚合物的合成

第28卷第3期合成纖維工業(yè)Vol 28 No. 32005年6月CHINA SYNTHETIC FIBER INDUSTRYSynthesis of polyglycolide- polyethyleneglycol-polyglycolidetriblock copolymerDuan Jiufang, Zheng Yubin, Chang JunDepartment of Polymer Science, Dalian University of Technology, Dalian 116012)CLC number: TQ340 63 Document code: A Article ID:1001-0041(2005)03-0035-02A triblock polymer of polyglycolide-polyethyleneglycoI- Reagent Factory, Furanidine by Tianjing Tianzheng Reagentpolyglycolide is mostly produced by ring-open polymerization, Factory and trimethylamine by Shenyang Xinxi Reagent Facto-wherein hydrophilic polyethyleneglycol is present in the center ry. Other chemicals were purchased from Dalianand the hydrophobic polyglycolide is located at both endsIR spectra were recorded with a Nicolet-20DXB IR spec-Polymers making hydrophobic polyglycolide hydrophilic canphotometer as KBr pellets. H NMR spectravent and 1% by volume of tetramethylsilane(TMs)as an in-The ring-open polymerization needs strict reaction condi- temal reference. The glass-transition temperature(T.)ofions and high cost. This triblock polymer can be produced by the polymeric products was determined by differential scan-solution polymerization. This technique has simple process ning calorimetry(DSC)with a 910s thermal analyzer at aand provides active groups, chlorine, at both ends of theheating rate of 10 C/min. The crystallinity of the polymerymer which could be further functionalized easilwas measured on an XD3-A Wide-angle X-ray diffraction1 Experimenta(WAXD)apparatus.1.1 Reagents and instruments1.2 Preparation of polyglycolide-polyethyleneglycol-All chemicals were in analytical grade. Chloracetic acid polyglycolide triblock polymerwas offered by Tianjing Guangfu Fine Chemistry Institute,The reaction for the synthesis of the triblock polymer ispolyethyleneglycol( PEG) by Guangzhou Medical Companyas folleCICH, COOHSOC\, CICH, COCIH(OCH2CH2O),H+C!CH2COCl→→CCH2C∈OCH2CH2O分,CCH2C1Et,NCICH, C-